排序方式： 共有17条查询结果，搜索用时 546 毫秒
1.
目的：探讨益气和胃胶囊联合八段锦治疗慢性胃炎（CG）伴焦虑、抑郁的疗效及其对炎症因子、免疫功能等的影响。方法：选取100 例CG伴焦虑、抑郁的患者为研究对象,按随机数字表法将其分为2组,每组各50 例。对照组行西医常规治疗,治疗组在对照组基础上加用益气和胃胶囊联合八段锦治疗。比较2组综合疗效、焦虑自评量表（SAS）和抑郁自评量表（SDS）评分、患者免疫功能和炎症因子指标变化、不良反应及治疗后6个月生活质量。结果：总有效率治疗组为96.00%（48/50）,对照组为72.00%（36/50）,2组比较,差异有统计学意义（P＜0.01）;治疗前2组SAS与SDS评分、免疫功能及炎症因子指标比较,差异均无统计学意义（P＞0.05）,治疗后2组SAS、SDS评分较治疗前均明显下降,且治疗组治疗后SAS、SDS评分低于对照组,差异均有统计学意义（P＜0.01）;治疗后2组CD3+、CD4+和CD4+/CD8+水平较治疗前显著提高,且治疗组升高幅度优于对照组,差异均有统计学意义（P＜0.05）;治疗后2组白细胞介素（IL）-6、IL-7及转化生长因子（TGF）-β1水平较治疗前显著降低,且治疗组降低幅度大于对照组（P＜0.05或P＜0.01）;不良反应发生率治疗组为2.00%（1/50）,对照组为20.00%（10/50）,2组比较,差异有统计学意义（P＜0.01）;出院后6个月随访,生活质量（QOL-100）评分治疗组高于对照组,差异有统计学意义（P＜0.01）。结论：在CG伴焦虑、抑郁的西医常规治疗基础上加用益气和胃胶囊联合八段锦治疗可改善患者焦虑、抑郁症状,提高免疫功能和生活质量,减少炎症反应和不良反应,值得临床推广。 相似文献
2.
目的：观察蛭龙活血通瘀胶囊及其拆方对动脉粥样硬化（AS）大鼠内皮素（ET）-1和一氧化氮（NO）的影响,并探讨其组方的合理性。方法：随机将110只健康雄性SD大鼠分为11组,分别为空白组、模型组、阿托伐他汀组、全方组和拆方1~7组,每组各10只,除空白组外其余各组均制备AS大鼠模型。阿托伐他汀组大鼠予以阿托伐他汀钙片干预,全方组予以黄芪、桂枝、大血藤、地龙、水蛭干预,拆方1组予以黄芪、桂枝、大血藤干预,拆方2组予以黄芪、地龙、水蛭干预,拆方3组予以黄芪干预,拆方4组予以桂枝、地龙干预,拆方5组予以桂枝、水蛭干预,拆方6组予以大血藤、地龙干预,拆方7组予以大血藤、水蛭干预,于实验第120天后检测各组大鼠治疗前后的血清ET- 1、NO水平。结果：蛭龙活血通瘀胶囊全方组较拆方组降低血清ET-1浓度和提高血清NO浓度的作用更为明显,诸药中影响大鼠血清ET-1、NO含量最显著的是黄芪。结论：蛭龙活血通瘀胶囊全方组中多种药味合用后,对降低AS大鼠血清ET-1和提高NO含量有明显的协同作用,方中多种药物均可保护内皮功能,且影响大鼠血清ET-1、NO含量最显著的药味是黄芪。 相似文献
3.
目的：观察舒肝化瘀方联合熊去氧胆酸胶囊（UDCA）治疗原发性胆汁性胆管炎（PBC）的临床疗效。方法：将50例PBC患者随机分为治疗组和对照组,每组各25例。对照组给予UDCA治疗,治疗组在对照组的基础上联合舒肝化瘀方治疗。2组疗程均为 48 周,观察2组治疗前后的主要症状、体征及肝功能指标、肝纤维化指标和不良反应发生情况。结果：治疗48周后治疗组中医证候总积分得到明显改善,2组中医证候疗效总有效率治疗组为92.00%（23/25）,对照组为84.00%（21/25）,组间比较,差异有统计学意义（P<0.01）。2组肝功能与肝纤维化各项指标均较治疗前明显改善（P<0.01）,且治疗组改善幅度优于对照组（P<0.01）。治疗期间2组均无明显不良反应。结论：舒肝化瘀方联合UDCA治疗PBC抗肝纤维化及改善肝功能疗效显著,安全性好,优于单用UDCA治疗。 相似文献
4.
研究卡托普利生物黏附型缓释胶囊(Captopril/bioadhesive sustained-release capsules,CBSRCs)在大鼠体内的药动学,通过建立高效液相色谱(HPLC)-紫外检测法测定卡托普利(Captopril,Cap)的血药浓度,研究了大鼠灌胃CBSRCs和卡托普利普通片(Captopril ordinary tablet,COT)各5 mg/kg后16 h内的药动学,DAS 2.0软件计算出相应的药动学参数,t检验比较两种制剂的药动学参数。结果表明,Cap浓度在12.5～800μg/L范围内线性关系良好(r=0.998 7),最低检测限为12.5μg/L,平均回收率为99.40%,平均日内RSD为3.97%,平均日间RSD为4.84%;单剂量口服CBSRCs和COT,Tmax分别为(3.12±0.67),(1.53±0.27)h;Cmax为(722.97±133.68),(1 114.47±208.36)μg/L;T1/2α为(1.88±0.38),(1.15±0.21)h;T1/2β为(3.76±0.75),(2.87±0.59)h;CL为(2.87±0.51),(3.43±0.67)L/h,Vd为(10.98±1.90),(13.21±2.57)L;AUC0-t为(4 856.03±835.46),(4 616.29±915.49)μg.h/L;AUC0-∞为(5 218.39±1 037.58),(4 705.83±894.56)μg.h/L。CBSRCs和COT相比,T1/2α,T1/2β,AUC0-t,AUC0-∞,CL,Vd,Tmax,Cmax差异显著(P0.05或0.01)。说明CBSRCs与市售COT在大鼠体内的药动学特征差异具有显著性,说明高效液相色谱-紫外检测器测定Cap含量的方法稳定,结果准确可靠。CBSRCs与市售COT相比,CBSRCs显著改善了卡托普利原药的药动学性质,具有缓释和长效的作用。 相似文献
5.
Setting minimum head capsule abundance and taxa deletion criteria in chironomid-based inference models 总被引：6，自引：0，他引：6
Criteria for removing training set lakes and taxa in chironomidbased inference models, due to low abundances, have largely been ad hoc. We used an anoxia inference model and a hypolimnetic oxygen model from southcentral Ontario to determine what effect subfossil head capsule abundance and taxa deletion criteria have on fossil inference statistics. Results from six training set lakes suggest that a minimum abundance of 40–50 head capsules is sufficient for use in inference models, however more diverse samples likely require more than 50 head capsules. Taxa deletion criteria substantially improved the predictive ability of inference models (lowered the root mean squared error of prediction (RMSEP)). The common practice of including taxa with only 2% abundance in at least two lakes was one of the deletion criteria that much improved inference models. Similar deletion criteria, such as 2% in at least 3 lakes and 3% in at least 1 lake, produced comparable improvements (up to 18% reduction in RMSEP). 相似文献
6.
目的：探讨蛭龙活血通瘀胶囊(以下简称“ZL”)对H2O2诱导细胞氧化损伤的保护作用。方法：以正常H9C2心肌细胞、PC12细胞作为对照,分别以不同浓度的H2O2处理细胞4 h,建立氧化损伤模型;在H2O2处理细胞前用ZL预处理24 h,作为ZL药物组,采用CCK-8法检测以上各组细胞存活率。结果：与未经H2O2处理的细胞比较,400 μmol/L H2O2处理的H9C2心肌细胞存活率下降至(47.25±4.14)%（P<0.01）;600 μmol/L H2O2处理的PC12细胞存活率下降至(52.53±4.31)%（P<0.01）;经10～320 mg/ml的ZL预处理后,H9C2心肌细胞、PC12细胞的存活率均高于模型组,差异有统计学意义（P<0.05）。结论：ZL对H2O2诱导的H9C2心肌细胞、PC12细胞氧化损伤有保护效果。 相似文献
7.
目的：研究补肺养心汤对冠心病心力衰竭患者中医证候及心功能的影响。方法：将94 例冠心病心力衰竭患者按随机数字表法分为治疗组和对照组,每组各47 例。对照组予以螺内酯、呋塞米、阿司匹林肠溶片等常规西药治疗,治疗组在对照组基础上联合补肺养心汤治疗,2组均以4周为1个疗程,共治疗3个疗程。治疗后比较2组的中医证候（心悸、气短、胸胁作痛）积分及心功能指标左心室射血分数（LVEF）、左心室收缩末期内径（LVESD）及左心室舒张末期内径（LVEDD）变化。结果：总有效率治疗组为85.11%（40/47）,高于对照组的63.83%（30/47）,差异有统计学意义（P＜0.05）;治疗后2组患者心悸、气短、胸胁作痛等中医证候积分及LVEDD、LVESD水平较治疗前降低,LVEF水平较治疗前升高,且治疗组改善幅度较对照组更为明显（均P＜0.05）。结论：补肺养心汤可有效缓解冠心病心力衰竭患者的临床症状,改善心功能,促进病情恢复。 相似文献
8.
A multidisciplinary, high-resolution paleoecological study (Lepidoptera and plant remains, macroscopic charcoal, pollen) was conducted on a 4000-yr peat monolith extracted from the margin of an ombrotrophic peatland on Anticosti Island (Gulf of St. Lawrence, eastern Canada) to reconstruct the long-term natural disturbances (insect outbreaks, forest fires) of a balsam fir/spruce forest. We hypothesized that an activity of insect defoliators (spruce budworm, hemlock looper) was the main disturbance factor of conifer forests during the Late Holocene. The earliest remains of spruce budworm and hemlock looper were found ca. 3220 and 2350 cal yr BP, respectively. Peaks of insect head capsules occurred from ca. 1640 to ca. 625 cal yr BP. Low balsam fir pollen concentrations during this period suggest a lengthy episode ( 1000 yr) of high insect activity, resulting in extensive fir dieback and mortality. The long-term dynamics of the pristine balsam fir/spruce forests were mainly governed by the activity of insect defoliators. The limited extent and possibly the low occurrence of forest fires in the maritime environment of Anticosti Island allowed the development of mature coniferous stands propitious for insect infestations. Insect head capsules appeared to be a useful and effective tool for establishing insect presence and activity during the Holocene. 相似文献
9.
Brian Morton 《Marine pollution bulletin》2009,58(10):1530-38
Over a 52-month period beginning in May 2004 and concluding in August 2008, and coinciding with the period over which TBT was banned as a ship anti-foulant globally, a population of the dogwhelk, Nucella lapillus, was studied for changes in population size and structure, and reproduction. During the study period, the size of the population of N. lapillus on the Mewsbrook Groyne at Littlehampton on the southeastern coast of England grew from ∼25 individuals to >500, i.e., a 20-fold increase. Similarly, population structure normalised to reveal a maximum age of up to ∼3 years. The numbers of egg capsules produced by the N. lapillus population also grew over the study, again by a factor of 20, and the length of the breeding season increased from 7 months in 2004-2005 and 2005-2006 to 11 months in 2006-2007 and 2007-2008. Such changes were reflected in the incidence of imposex from Vas Deferens Index Stages 3 and 4 in 2003 to zero commencing in 2008 and continuing into 2009.Due to a lack of confirmatory chemical data, the changes in population size, structure and reproduction herein reported upon for N. lapillus cannot be correlated positively with changes in ambient TBT levels, but they can and are correlated with freedom from imposex. This is the first time such a dramatic recovery from imposex, following the banning of TBT, has been documented. 相似文献
10.
目的：观察李扬声自拟定眩方联合氟桂嗪胶囊治疗眩晕的临床疗效。方法：将76 例眩晕患者随机分为治疗组和对照组,每组各38 例。对照组予氟桂嗪（脑灵）胶囊治疗,治疗组在对照组基础上加用李扬声自拟定眩方治疗。比较2组临床疗效,临床症状与功能评分,左侧椎动脉（LVA）、右侧椎动脉（RVA）血流动力学指标,血脂水平。结果：总有效率治疗组为89.47%（34/38）,对照组为73.68%（28/38）,2组比较,差异有统计学意义（P<0.05）。2组临床症状与功能评分、两侧椎动脉最大血流速度及其口径和血脂各项指标水平治疗前后组内比较及治疗后组间比较,差异均有统计学意义（P<0.05）。结论：李扬声自拟定眩方联合氟桂嗪胶囊治疗眩晕临床疗效显著,能有效缓解患者临床症状,改善椎动脉血流动力学及血脂各项指标水平,值得临床推广应用。 相似文献